تفاعل #466175

معادلة التفاعل

tert-butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate

trifluoroacetic acid

→

[3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid

المردود 82.5%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىat RT
2. 2
   أخرىThe reaction mixture is evaporated in a vacuum
3. 3
   أخرىthe solution is evaporated to dryness
4. 4
   ترشيحfiltered off under suction
5. 5
   غسيلwashed with water
6. 6
   أخرىdried

الإجراء التجريبي

142 mg of tert-butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate is stirred in 1.1 ml of methylene chloride and 1.1 ml of trifluoroacetic acid (TFA) for 2 hrs. at RT. The reaction mixture is evaporated in a vacuum, the residue is taken up in water and the solution is evaporated to dryness. The solid is suspended in water, adjusted to pH 8 with 1N ammonia while stirring, filtered off under suction, washed with water and dried. There are obtained 101 mg of [3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid, m.p. 284° C., MS: 350 (M+H)+.

المصدر