تفاعل #466174

ord-c68db61d470048ba9a00c0facda94b3f

معادلة التفاعل

Cc1nc(NC(=N)N)sc1C(=O)O
2-Guanidino-4-methyl-thiazole-5-carboxylic acid
CC(C)(C)OC(=O)COc1cccc(N)c1
tert-butyl (3-amino-phenoxy)-acetate
→
Cc1nc(NC(=N)N)sc1C(=O)Nc1cccc(OCC(=O)OC(C)(C)C)c1
tert-butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate

المتفاعلات

Cc1nc(NC(=N)N)sc1C(=O)O
2-Guanidino-4-methyl-thiazole-5-carboxylic acid
CC(C)(C)OC(=O)COc1cccc(N)c1
tert-butyl (3-amino-phenoxy)-acetate

الكواشف

لا شيء

المذيبات

CCOC(C)=O.ClCCl
methylene chloride ethyl acetate

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

2-Guanidino-4-methyl-thiazole-5-carboxylic acid is reacted with tert-butyl (3-amino-phenoxy)-acetate in the same manner as in Example 3. Chromatography on silica gel with methylene chloride-ethyl acetate and methylene chloride-alcohol gives 176 mg of tert-butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate, m.p. 204° C., MS: 406 (M+H)+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06297266B1uspto-grants-2001_10