تفاعل #466173

معادلة التفاعل

ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate

hydrochloric acid

→

[4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture is evaporated to dryness in a vacuum

الإجراء التجريبي

330 mg of ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate are stirred at RT for 11 hrs. in 6 ml of 25% hydrochloric acid. The reaction mixture is evaporated to dryness in a vacuum and the residue is trituraited in MeCN. There are obtained 293 mg of [4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid hydrochloride (1:1); m.p. 273° C., MS: 350 (M+H)+.

المصدر