تفاعل #466172

معادلة التفاعل

2-guanidino-4-methyl-thiazole-5-carboxylic acid

ethyl 4-amino-phenyloxyacetate hydrochloride

HBTU

→

ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate

المردود 48.8%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe working up and purification
2. 2
   أخرىCrystallization from acetonitrile (MeCN)

الإجراء التجريبي

400 mg of 2-guanidino-4-methyl-thiazole-5-carboxylic acid, 463 mg of ethyl 4-amino-phenyloxyacetate hydrochloride, 6 ml of DMF, 0.67 ml of N-MM and 759 mg of HBTU are stirred at RT for 22 hrs. The working up and purification are effected as described in Example 1. Crystallization from acetonitrile (MeCN) gives 368 mg of ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate, m.p. 223° C.;, MS: 378 (M+H)+.

المصدر