تفاعل #465961

معادلة التفاعل

3,4,5,6-tetrafluoro-2-cyanopyridine

ammonium hydroxide

→

4-amino-3,5,6-trifluoro-2-cyanopyridine

المردود 92.0%

المذيبات

DMF

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solid was collected
2. 2
   أخرىair dried

الإجراء التجريبي

To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.

المصدر