تفاعل #465937

معادلة التفاعل

isatin

HCl

→

acridine acid

المذيبات

KOH

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was cooled
2. 2
   ترشيحfiltered after 1 h
3. 3
   غسيلwashed with water
4. 4
   أخرىThe solid was air-dried over night
5. 5
   غسيلwashed with CH2Cl2
6. 6
   أخرىair-dried

الإجراء التجريبي

The isatin product from step (a) was refluxed in 300 mL of 10% KOH solution in water for ca. 48 h. The solution was cooled and acidified to pH 2-3 with HCl. The yellow solid was suction filtered after 1 h and then washed with water. The solid was air-dried over night, washed with CH2Cl2 and then air-dried yielding 23.76 g of the acridine acid. 1H NMR (DMSO-d6) δ 7.72-8.30 (m, 7H).

المصدر