تفاعل #46585

معادلة التفاعل

2-Methoxyethylamine

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

DIEA

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title compound

المردود 90.0%

2-Amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine

المردود 90.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزthen was concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   استخلاصthe solution was extracted with ethyl acetate
4. 4
   غسيلThe combined organic extracts were washed with brine
5. 5
   تجفيفdried over Na2SO4
6. 6
   تركيزconcentrated

الإجراء التجريبي

2-Methoxyethylamine (1.49 mL, 17.16 mmole) was added to a solution of 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide (1.49 g, 4.29 mmole) and DIEA (2.24 mL, 12.87 mmole) in CH2Cl2 (10 mL) at RT. The reaction was stirred overnight then was concentrated in vacuo. The residue was diluted with water and the solution was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated to afford the title compound (1.00 g, 90%) as a light brown liquid after drying in vacuo: MS (ES) m/e 260/262 (M+H)+.

المصدر