تفاعل #465479

معادلة التفاعل

N-(6-chloro-2-methylamino-pyrimidin-4-yl)-3-trifluoromethyl-benzenesulfonamide

methylamine hydrochloride

triethylamine

→

N-(2,6-bis-methylamino-pyrimidin-4-yl)-3-trifluoromethyl-benzenesulfonamide

المردود 56.4%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe entire reaction mixture
2. 2
   أخرىwas partitioned in ethyl acetate/water
3. 3
   استخلاصextracted
4. 4
   أخرىThe residue was recrystallized in MeOH

الإجراء التجريبي

0.10 g (0.00027 mol) of N-(6-chloro-2-methylamino-pyrimidin-4-yl)-3-trifluoromethyl-benzenesulfonamide was dissolved in 5 ml of EtOH, treated with 0.27 g (0.004 mol) of methylamine hydrochloride and 1 ml (0.007 mol) of triethylamine and stirred in an autoclave at 145° C. for 17 hours. The entire reaction mixture was partitioned in ethyl acetate/water and extracted. The residue was recrystallized in MeOH. There was obtained 0.055 g (56%) of N-(2,6-bis-methylamino-pyrimidin-4-yl)-3-trifluoromethyl-benzenesulfonamide as white crystals; m.p. 234-235° C.

المصدر