تفاعل #465448

معادلة التفاعل

4-amino-N-(6-chloro-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide

ethylamine

→

4-amino-N-(6-ethylamino-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide

المردود 56.0%

المذيبات

ethanol

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONtreated in an ultra-sound bath for 15 minutes
2. 2
   ترشيحThe precipitate was filtered off
3. 3
   workup.DISSOLUTIONdissolved in 10 ml of 0.1N NaOH
4. 4
   ترشيحfiltered
5. 5
   ترشيحThe precipitate was filtered off under suction
6. 6
   غسيلwashed with water
7. 7
   أخرىdried

الإجراء التجريبي

0.314 g (0.001 mol) of 4-amino-N-(6-chloro-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide and 6.6 ml (0.1 mol) of ethylamine were stirred in 15 ml of ethanol in an autoclave at 130° C. for 3 hours. The reaction mixture was freed from solvent, the residue was suspended in 8 ml of ethanol and treated in an ultra-sound bath for 15 minutes. The precipitate was filtered off, dissolved in 10 ml of 0.1N NaOH and filtered. The filtrate was adjusted to pH 6 with 01N HCl. The precipitate was filtered off under suction, washed with water and dried. There was obtained 0.18 g (56%) of 4-amino-N-(6-ethylamino-2-methylamino-pyrimidin-4-yl)-benzenesulfonamide as white crystals; m.p.: 252° C. (dec.).

المصدر