تفاعل #465417

معادلة التفاعل

1-n-butyl-4-hydroxymethyl-5-(2-methoxymethoxy-4-methoxyphenyl)-1H-imidazole

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title compound

المردود 98.2%

1-n-Butyl-5-(2-methoxymethoxy-4-methoxyphenyl)-1H-imidazole-4-carboxaldehyde

المردود 98.2%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   أخرىthe filtrate was evaporated to dryness

الإجراء التجريبي

To a solution 1-n-butyl-4-hydroxymethyl-5-(2-methoxymethoxy-4-methoxyphenyl)-1H-imidazole (0.05 g, 0.16 mmol) in toluene (5 mL) was added manganese oxide (0.04 g, 0.47 mmol). The mixture was stirred for 5 h at room temperature. The mixture was filtered and the filtrate was evaporated to dryness. Flash column chromatography (1:4 ethyl acetate/hexane) of the residue afforded the title compound as an oil (0.05 g, 94%). 1H NMR (250 MHz, CDCl3)δ 9.65 (s, 1H), 7.58 (s, 1H), 7.13 (d, 1H), 6.80 (d, 1H), 6.65 (dd, 1H), 5.05 (s, 2H), 3.90 (s, 3H) 3.80 (t, 2H), 3.35 (s, 3H), 1.55 (quintet, 2H), 1.25 (quintet, 2H), 0.83 (t, 3H).

المصدر