تفاعل #46458

معادلة التفاعل

2-Bromo-4-methyl-6-iodophenol

cinnamyl bromide

Diisopropylethylamine

→

1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene

المردود 101.2%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe DMF was removed under vacuum, and 1M HCl
2. 2
   workup.ADDITIONwas added until the residue
3. 3
   استخلاصThe mixture was extracted with ethyl acetate
4. 4
   تجفيفthe combined organic phase was dried over magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

2-Bromo-4-methyl-6-iodophenol (7.82 gm, 25 mmol) and cinnamyl bromide (4.93 g, 25 mmol) were added to DMF (20 ml). Diisopropylethylamine (5.3 ml, 30.4 mmol) was added and the mixture heated to 60° C. for 15 minutes and then allowed stir for 16 hours at room temperature. The DMF was removed under vacuum, and 1M HCl was added until the residue was acidic. The mixture was extracted with ethyl acetate, and the combined organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 100% yield).

المصدر