تفاعل #464485

معادلة التفاعل

1-hydroxy-1-(4,5-diphenyloxazol-2-yl)-2-(3-methoxybenzyl)cyclopentane

potassium hydrogensulfate

→

1-(4,5-diphenyloxazol-2-yl)-5-(3-methoxybenzyl)-cyclopentene

المردود 104.4%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux
2. 2
   درجة الحرارةAfter being cooled
3. 3
   غسيلthe solution was washed with water, saturated sodium bicarbonate aqueous solution and brine
4. 4
   أخرىevaporated in vacuo
5. 5
   أخرىThe oily residue was chromatographed on silica gel

الإجراء التجريبي

To a solution of 1-hydroxy-1-(4,5-diphenyloxazol-2-yl)-2-(3-methoxybenzyl)cyclopentane (8.0 g) in toluene (160 ml) was added potassium hydrogensulfate (2.6 g), and the solution was stirred for 1 hour under reflux. After being cooled, the solution was washed with water, saturated sodium bicarbonate aqueous solution and brine and evaporated in vacuo. The oily residue was chromatographed on silica gel to afford a mixture (8.0 g) of 1-(4,5-diphenyloxazol-2-yl)-5-(3-methoxybenzyl)-cyclopentene and 1-(4,5-diphenyloxazol-2-yl)-2-(3-methoxybenzyl)cyclopentene.

المصدر