تفاعل #4640

معادلة التفاعل

2,4-dihydroxybenzoic acid methyl ester

epichlorohydrin

potassium carbonate

→

4-(2,3-epoxypropoxy)salicylic acid methyl ester

ظروف التفاعل

الإجراء التجريبي

By refluxing 34 g of 2,4-dihydroxybenzoic acid methyl ester with 185 g of epichlorohydrin and 35 g of potassium carbonate for 2 to 3 hours, and chromatographing the crude product on 100 g of silica gel (elution with toluene), 4-(2,3-epoxypropoxy)salicylic acid methyl ester having a melting point of 53°-55° is obtained.

المصدر