تفاعل #463502

معادلة التفاعل

9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

chloroform

→

title compound

المردود 61.6%

9-Methoxy-5-methyl-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline

المردود 61.6%

المذيبات

decalin

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 6 hours
2. 2
   درجة الحرارةAfter being cooled
3. 3
   ترشيحthe mixture was filtered
4. 4
   أخرىthe filtrate was evaporated in vacuo
5. 5
   أخرىThe resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1)

الإجراء التجريبي

To a solution of 4.9 g of 9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline in 30 ml of decalin was added 0.97 g of palladium on activated carbon (Pd 10%) and the mixture was refluxed for 6 hours. After being cooled and an addition of 200 ml of chloroform, the mixture was filtered and the filtrate was evaporated in vacuo. The resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1) to give 3.0 g of the title compound.

المصدر