تفاعل #4634

معادلة التفاعل

N-(2-hydroxyethyl)-N'-(2-hydroxybenzyl)urea

potassium carbonate

epichlorohydrin

→

N-[2-(2,3-epoxypropoxy)benzyl]-N'-(2-hydroxyethyl)urea

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solids are then suction-filtered whilst hot,
2. 2
   غسيلwashed with acetonitrile
3. 3
   تركيزthe filtrate is concentrated by evaporation in vacuo
4. 4
   أخرىThe oil remaining crystallises when
5. 5
   workup.WAITleft
6. 6
   أخرىis recrystallised from 320 ml of ethyl acetate, with carbon treatment

الإجراء التجريبي

A mixture of 29.2 g of N-(2-hydroxyethyl)-N'-(2-hydroxybenzyl)urea, 440 ml of epichlorohydrin and 38.9 g of potassium carbonate is stirred for 6 hours at 90°. The solids are then suction-filtered whilst hot, washed with acetonitrile and the filtrate is concentrated by evaporation in vacuo. The oil remaining crystallises when left to stand and is recrystallised from 320 ml of ethyl acetate, with carbon treatment. The resulting epoxide melts at 96°-99°.

المصدر