تفاعل #463235

معادلة التفاعل

octan-2-one

hypophosphorus acid

→

1-hydroxy-1-methylheptylphosphonous acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe Dowex is removed by filtration
2. 2
   أخرىThe filtrate is evaporated to an oily residue, which
3. 3
   workup.DISSOLUTIONis dissolved in ethyl acetate
4. 4
   غسيلwashed with water, brine
5. 5
   تجفيفdried (MgSO4)
6. 6
   أخرىRemoval of the solvent

الإجراء التجريبي

A mixture of octan-2-one (3.76 g, 0.29M) and hypophosphorus acid (91.5%, 2.09 g, 0.029M) is heated at 100° C. for 12 hours in the presence of Dowex 50W x 2 ion exchange resin (1 ml, aqueous slurry). The mixture is cooled to room temperature, methanol (50 ml) is added and the Dowex is removed by filtration. The filtrate is evaporated to an oily residue, which is dissolved in ethyl acetate, washed with water, brine, then dried (MgSO4). Removal of the solvent gives 1-hydroxy-1-methylheptylphosphonous acid.

المصدر