تفاعل #46295

معادلة التفاعل

4-hydroxybutylamine

tert-butyl bromoacetate

→

tert-Butyl[(4-hydroxybutyl)amino]acetate

المذيبات

diethyl ether

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   غسيلThe product mixture was washed successively with aqueous NaHCO3, water, and brine
2. 2
   استخلاصThe organic extract
3. 3
   تجفيفwas dried over anhydrous sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated under vacuum
6. 6
   أخرىThis intermediate was used in the following reaction without further purification

الإجراء التجريبي

To a cold (0° C.) solution of 4-hydroxybutylamine (9.1 g, 101.8 mmol) in diethyl ether (100 mL), a solution of tert-butyl bromoacetate (7.4 g, 49.3 mmol) in diethyl ether (25 mL) was added dropwise over a period of 2 hours. The reaction mixture was allowed to warm up slowly to room temperature and stirred at the temperature overnight. The product mixture was washed successively with aqueous NaHCO3, water, and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. This intermediate was used in the following reaction without further purification.

المصدر