تفاعل #462200

معادلة التفاعل

α,α'-dichloro-o-xylene

triethylphosphine

triethylphosphonium chloride salt

→

2-(Chloromethyl)benzyltriethylphosphonium chloride

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىhad crystallized out of solution
2. 2
   ترشيحThe crystals were filtered
3. 3
   غسيلwashed with toluene (3×50 mL) and pentane (3×50 mL)
4. 4
   أخرىdried

الإجراء التجريبي

To a mixture of α,α'-dichloro-o-xylene (15.0 g, 86.0 mmol) in toluene (200 ml) was added triethylphosphine (6.3 ml, 43.0 mmol) under argon gas. The reaction mixture was stirred for several days at room temperature under argon after which time the triethylphosphonium chloride salt had crystallized out of solution. The crystals were filtered and washed with toluene (3×50 mL) and pentane (3×50 mL) and dried: 1H NMR (CDCl3) δ1.15-1.26 (dt, 9), 2.58-2.69 (m, 6H), 4.39-4.44 (d, 2H), 4.87 (s, 2H) , 7.31-7.34 (dd, 2H) , 7.43-7.46 (dd, 1H), 7.50-7.54 (m, 1H).

المصدر