تفاعل #46174

معادلة التفاعل

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester

p-toluene sulfonic acid

→

title compound

المردود 75.3%

3-phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate methyl ester

المردود 75.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was reacted for 1 hour at 70° C.
2. 2
   غسيلwashed with brine
3. 3
   استخلاصThe organic layer was extracted with ethyl acetate
4. 4
   تجفيفdried over anhydrous sulfonate sulfate
5. 5
   تركيزconcentrated
6. 6
   أخرىthe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9)

الإجراء التجريبي

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester (1.65 g, 4.0 mmol) prepared in (Step 5) of Example 1 was dissolved in methanol (160 ml) and p-toluene sulfonic acid (228 mg, 1.2 mmol) was added thereto. The mixture was reacted for 1 hour at 70° C., and then washed with brine. The organic layer was extracted with ethyl acetate, dried over anhydrous sulfonate sulfate, concentrated, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9) to obtain the title compound (yield 75.3%) as a red solid.

المصدر