تفاعل #46168

معادلة التفاعل

Hydroxy amine

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

hydrochloric acid

pyridine

→

1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile

المردود 45.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe organic layer extracted with ethyl acetate
2. 2
   غسيلwas washed with distilled water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2)

الإجراء التجريبي

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (200 mg, 0.547 mmol) was dissolved in ethanol. Hydroxy amine.hydrochloric acid (114 mg, 1.64 mmol) and pyridine (173 mg, 2.18 mmol) were added thereto and the mixture was stirred for 4 hours at 70° C. The organic layer extracted with ethyl acetate was washed with distilled water, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2) to obtain trails 1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile (95 mg, yield 45%) as a red solid,

المصدر