تفاعل #46167

معادلة التفاعل

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one

Copper (I) cyanide

ammonium chloride

→

title compound

المردود 83.3%

1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

المردود 83.3%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled
2. 2
   استخلاصThe organic layer was extracted with ethyl acetate
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)

الإجراء التجريبي

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one (1.0 g, 2.3 mmol) was dissolved in N,N-dimethylformamide (10 ml). Copper (I) cyanide (617 mg, 6.9 mmol) was added thereto and the mixture was stirred for 3 hours at 150° C. The mixture was cooled, and saturated ammonium chloride was added thereto. The organic layer was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain the title compound (700 mg, yield 80%) as a red solid.

المصدر