تفاعل #46166

معادلة التفاعل

sodium chloride

N-bromosuccinimide

2,2′-azobisisobutyronitrile

3-Phenyl-6-(3-phenylpropoxy)indene-1-one

→

title compound

المردود 60.0%

2-bromo-3-phenyl-6-(3-phenylpropoxy)indane-1-one

المردود 60.0%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane
2. 2
   تجفيفThe extract was dried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated
4. 4
   أخرىthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5)

الإجراء التجريبي

3-Phenyl-6-(3-phenylpropoxy)indene-1-one (200 mg, 0.586 mmol) was dissolved in carbon tetrachloride, and N-bromosuccinimide (313 mg, 1.75 mmol) and 2,2′-azobisisobutyronitrile (9.7 mg) were added thereto. Then, the mixture was refluxed for 1 hour under a 375 W tungsten lamp. After the reaction was completed, saturated sodium chloride was added thereto and extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5) to obtain title compound (147 mg, yield 60%) as a red solid.

المصدر