تفاعل #461460
ord-f3f45468458f416285c1aa50a55849c5
معادلة التفاعل
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىThe exothermic reaction
- 2أخرىAfter 15 min a solid precipitated from the orange solution
- 3ترشيحAfter 2 h at 0° C. the reaction mixture was filtered
- 4غسيلthe solid was washed twice with absolute ethanol and twice with chloroform
الإجراء التجريبي
To a stirred, cooled (0° C.) solution of 15.4 ml (0.25 mol) of propiolic acid in 200 ml of absolute ethanol under nitrogen was added 3.48 ml (0.025 mol) of triethylamine. After 5 min, 33 ml (0.28 mol) of thiobenzoic acid was added very cautiously and dropwise. The exothermic reaction led to the ethanol reaching reflux despite the ice-water bath. After 15 min a solid precipitated from the orange solution. After 2 h at 0° C. the reaction mixture was filtered and the solid was washed twice with absolute ethanol and twice with chloroform to afford 18.3 g (35% yield of cis-3-(benzoylthio)propenoic acid as a white powder.