تفاعل #4609

معادلة التفاعل

methanol

4-(5-bromo-2-pyrimidinyloxy)-3-chloroaniline

2-nitrobenzoylisocyanate

water

→

desired product

المردود 84.5%

N-(2-nitrobenzoyl)-N'-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]urea

المردود 84.5%

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىInto a flask, a solution obtained
2. 2
   workup.ADDITIONwas introduced
3. 3
   أخرىa solution obtained
4. 4
   workup.ADDITIONwas dropwise added
5. 5
   أخرىthe mixture was reacted at room temperature for 9 hours
6. 6
   أخرىAfter the completion of the reaction
7. 7
   ترشيحsubjected to filtration
8. 8
   غسيلwashed with hot water
9. 9
   أخرىThe crystals thereby obtained
10. 10
    ترشيحsubjected to filtration again

الإجراء التجريبي

Into a flask, a solution obtained by dissolving 6.80 g of the above 4-(5-bromo-2-pyrimidinyloxy)-3-chloroaniline in 30 ml of dioxane, was introduced, and a solution obtained by dissolving 5.76 g of 2-nitrobenzoylisocyanate in 30 ml of dioxane, was dropwise added thereto, and then the mixture was reacted at room temperature for 9 hours. After the completion of the reaction, the product was poured into water, subjected to filtration and washed with hot water. The crystals thereby obtained were put into methanol, and stirred, and then subjected to filtration again, to obtain 9.42 g of the desired product having a melting point of from 234 to 236° C.

المصدر