تفاعل #46022

معادلة التفاعل

{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}phenol

Cs2CO3

mesylate

→

phenyl ether

المذيبات

DMF

water

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained above and the reaction mixture
2. 2
   درجة الحرارةThe reaction mixture was then cooled to rt
3. 3
   استخلاصthe product was extracted with DCM
4. 4
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}phenol (2 mmol) was added to a solution of Cs2CO3 (10 eq., 20 mmol) in anhydrous DMF (5 ml). This was followed by addition of the mesylate obtained above and the reaction mixture was heated to 90° C. for 2-3 h. The reaction mixture was then cooled to rt, diluted with cold water and the product was extracted with DCM. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give desired phenyl ether.

المصدر