تفاعل #459441

معادلة التفاعل

4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid

thionyl chloride

→

4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid chloride

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 2.5 hours
2. 2
   أخرىis removed in vacuo
3. 3
   أخرىresulting oil
4. 4
   أخرىcrystallizes on standing
5. 5
   أخرىThe product is triturated with ether-hexane

الإجراء التجريبي

A mixture of 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid (2.1 g, 7.1 mmol) [J. Org. Chem., 38, 3034 (1973)], thionyl chloride (5 ml) and methylene chloride (20 ml) is refluxed for 2.5 hours. After cooling to room temperature the solvent is removed in vacuo and resulting oil crystallizes on standing. The product is triturated with ether-hexane to give 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid chloride; 2.0 g mp 104°-112°.

المصدر