تفاعل #459098

معادلة التفاعل

palmityl chloride

5-fluorouracil

dioxane

→

1-N-palmitoyl-5-fluorouracil

المردود 54.0%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   أخرىthe solvent was removed under reduced pressure (25 mm Hg)
3. 3
   غسيلthe residual solid was washed with hot hexane (50° C)
4. 4
   أخرىAny insoluble matter in the hot hexane was recrystallized from benzene

الإجراء التجريبي

2.6 g of 5-fluorouracil was suspended in 20 ml of absolute dioxane and 10 ml of absolute pyridine, and 15 g of palmityl chloride was added to the suspension followed by heating at 80° C for 1 hour while stirring. After completion of the reaction, the solvent was removed under reduced pressure (25 mm Hg), and the residual solid was washed with hot hexane (50° C). Any insoluble matter in the hot hexane was recrystallized from benzene to obtain 4.0 g of 1-N-palmitoyl-5-fluorouracil in a yield of 54%. Melting Point: 98° C.

المصدر