تفاعل #4584

معادلة التفاعل

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated for 7 hours
2. 2
   درجة الحرارةto reflux
3. 3
   أخرىwhile simultaneously separating
4. 4
   أخرىthe water of reaction
5. 5
   غسيلthe organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   أخرىdried
7. 7
   تركيزconcentrated

الإجراء التجريبي

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

المصدر