تفاعل #4582

معادلة التفاعل

phosgene

2-(1-methoxycarbonylethoxy)-benzenesulfonamide

n-butylisocyanate

phosgene

→

2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate

المردود 125.5%

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 30 minutes
2. 2
   درجة الحرارةthe solution is then cooled
3. 3
   تركيزconcentrated in vacuo

الإجراء التجريبي

A mixture of 12.9 g of 2-(1-methoxycarbonylethoxy)-benzenesulfonamide, 4.9 g of n-butylisocyanate and 0.1 g of diazabicyclooctane and 130 ml of xylene is refluxed for 30 minutes. Then 10 g of phosgene are passed into the solution at the same temperature over 90 minutes. Excess phosgene is expelled with nitrogen and the solution is then cooled and concentrated in vacuo, affording 17.7 g of 2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate in the form of a brownish oil which can be further used without purification.

المصدر