تفاعل #458198

معادلة التفاعل

4-(2-chloro-4-trifluoromethylphenoxy)phenol

methyl 4-bromo-3-methoxy-2-pentenoate

potassium carbonate

→

4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 48 hours
2. 2
   ترشيحAfter filtration
3. 3
   تركيزthe filtrate was concentrated
4. 4
   أخرىthe residue chromatographed on silia gel

الإجراء التجريبي

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)phenol (6.9 mmol.), methyl 4-bromo-3-methoxy-2-pentenoate (8.9 mmol.) and potassium carbonate (1.5 equis.) in acetone (15 ml.) is refluxed for 48 hours. After filtration, the filtrate was concentrated and the residue chromatographed on silia gel using 20% ethylacetate/hexane to give the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid.

المصدر