تفاعل #458197

معادلة التفاعل

4-(2-chloro-4-trifluoromethylphenoxy)phenol

ethyl 4-bromo-3-methoxy-2-pentenoate

potassium carbonate

→

4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis heated to about 130° for 2 hours
2. 2
   أخرىThereafter, DMF is removed
3. 3
   ترشيحThe residue is filtered
4. 4
   غسيلwashed with methylene dichloride
5. 5
   غسيلThe filtrate is washed
6. 6
   أخرىdried
7. 7
   أخرىevaporated to dryness

الإجراء التجريبي

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)phenol (1.16 g), ethyl 4-bromo-3-methoxy-2-pentenoate (1.74 g) and potassium carbonate (0.73 g) in DMF (5 ml.) is heated to about 130° for 2 hours. Thereafter, DMF is removed. The residue is filtered and washed with methylene dichloride. The filtrate is washed, dried and evaporated to dryness. The oily residue is subjected to prep. thin layer chromatography using 20% ethylacetate/hexane to yield the ethyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid, MS m/e 444 (M+).

المصدر