تفاعل #45788

معادلة التفاعل

2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide

→

N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the reaction
2. 2
   أخرىthe insoluble matter was removed by filtration
3. 3
   تركيزthe filtrate was concentrated under reduced pressure
4. 4
   أخرىto obtain the entitled compound
5. 5
   أخرىNot purified
6. 6
   أخرىthis was used in the next reaction as such

الإجراء التجريبي

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

المصدر