تفاعل #4577

معادلة التفاعل

methyl 5-chlorooxindole-3-carboxylate

phenylisocyanate

→

Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

المذيبات

toluene

—

petroleum ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةto reflux overnight
3. 3
   درجة الحرارةThe reaction mixture was cooled
4. 4
   أخرىto give
5. 5
   ترشيحafter filtration
6. 6
   أخرىdrying

الإجراء التجريبي

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

المصدر