تفاعل #457067

معادلة التفاعل

4-Benzyl-2-chloromethylmorpholine

4-(2-hydroxyethyl)piperazine

→

4-benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is heated
2. 2
   استخلاصthe mixture is extracted with chloroform
3. 3
   تجفيفthe extract is dried over magnesium sulfate
4. 4
   أخرىThe residue thus obtained
5. 5
   تركيزis concentrated under reduced pressure

الإجراء التجريبي

4-Benzyl-2-chloromethylmorpholine (15 g) and 4-(2-hydroxyethyl)piperazine (25 ml) are mixed, and the mixture is heated with stirring at 130° C. for five hours. After the reaction is complete, the mixture is extracted with chloroform, and the extract is dried over magnesium sulfate. The residue thus obtained is concentrated under reduced pressure to give 4-benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine (16 g).

المصدر