تفاعل #45670

معادلة التفاعل

2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile

ethyl triethoxyacetate

→

compound

المردود 80.0%

Ethyl 6-bromo-4-cyano-7-fluoro-5-methyl-1,3-benzoxazole-2-carboxylate

المردود 80.0%

المذيبات

n-hexane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   ترشيحthe precipitated solid was collected by filtration
3. 3
   غسيلwashed in diethyl ether

الإجراء التجريبي

Under nitrogen atmosphere, a mixture of 2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile (I-75) (6.67 g, 27.2 mmol) and ethyl triethoxyacetate (24.0 g, 54.4 mmol) was stirred at 130° C. for 15 hours. After cooling, n-hexane was added to the reaction liquid, and the precipitated solid was collected by filtration. The obtained solid was suspended and washed in diethyl ether to obtain the entitled compound (7.10 g, 80%) as a pale dark brown solid.

المصدر