تفاعل #456405

معادلة التفاعل

methylamine

1-(5-amino-4-fluoro-2-methylphenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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title compound

1-(5-Amino-4-fluoro-2-methylphenyl)-8-chloro-6-fluoro-7-methylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
2. 2
   workup.ADDITIONa mixed liquid of ethanol and diethyl ether was added to the residue
3. 3
   workup.WAITthe mixture was left
4. 4
   workup.WAITto stand overnight
5. 5
   ترشيحSolids deposited were collected by filtration

الإجراء التجريبي

A 40% aqueous solution (100 mg) of methylamine and 1-(5-amino-4-fluoro-2-methylphenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, a mixed liquid of ethanol and diethyl ether was added to the residue, and the mixture was left to stand overnight. Solids deposited were collected by filtration to obtain the title compound (63 mg) as colorless crystals.

المصدر