تفاعل #456274

معادلة التفاعل

1-(6-chlorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione

4-sulfamoylphenylhydrazine hydrochloride

→

4-[5-(6-chlorobenzothiazol-2-yl)-3-difluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide

ظروف التفاعل

الإجراء التجريبي

The procedure of Example 9 was repeated using 1-(6-chlorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-sulfamoylphenylhydrazine hydrochloride as the starting materials to obtain 4-[5-(6-chlorobenzothiazol-2-yl)-3-difluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide. NMR(DMSO-d6) δ: 7.23 (1H, t, J=54.1 Hz), 7.56 (2H, bs), 7.57 (1H , s), 7.56-7.60 (1H, m), 7.76-7.80 (2H, m), 7.93-7.97 (3H, m), 8.36 (1H, d, J=2.3 Hz); mp 242-244° C. (toluene)

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