تفاعل #455979

معادلة التفاعل

4-chloro-2-fluorotoluene

H2SO4

hydrobromic acid

2,2'-azobis(2-methylpropionitrile)

hydrogen peroxide

2,2'-azobis(2-methylpropionitrile)

→

4-chloro-2-fluorobenzyl bromide

المذيبات

chlorobenzene

chlorobenzene

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was then stirred at 70° C. for 1 hour

الإجراء التجريبي

361.5 g of 4-chloro-2-fluorotoluene, 520 g of chlorobenzene, 6 g of conc. H2SO4, 467 g of 47% strength hydrobromic acid and 2.7 g of 2,2'-azobis(2-methylpropionitrile) were mixed at 70° C. in a 4 l stirred apparatus. 620.5 g of a 10% strength aqueous hydrogen peroxide solution and a solution of 16.5 g of 2,2'-azobis(2-methylpropionitrile) in 270 g of chlorobenzene were simultaneously added dropwise over the course of 1.5 hours. The mixture was then stirred at 70° C. for 1 hour. GC analysis of the org. phase:

المصدر