تفاعل #45579

معادلة التفاعل

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

المذيبات

brine

ظروف التفاعل

المعالجة

1. 1
   استخلاصfollowed by extraction twice with ethyl acetate
2. 2
   غسيلthe organic layer was washed three times with saturated brine
3. 3
   تجفيفdried over anhydrous magnesium sulfate

الإجراء التجريبي

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

المصدر