تفاعل #45564

معادلة التفاعل

1-fluoro-2-methoxy-5-methyl-3-nitrobenzene

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compound

المردود 81.2%

3-Fluoro-2-methoxy-5-methylaniline

المردود 81.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration and concentration under reduced pressure
2. 2
   تركيزthe eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure

الإجراء التجريبي

5% Palladium-carbon (wet, 100 mg) was added to a methanol (5 ml) solution of 1-fluoro-2-methoxy-5-methyl-3-nitrobenzene (I-25) (250 mg, 1.35 mmol), followed by stirring under hydrogen atmosphere for 30 minutes. After filtration and concentration under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure to obtain the entitled compound (170 mg, 81%) as a yellow oily substance.

المصدر