تفاعل #4549

معادلة التفاعل

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine

magnesium oxide

ethanol

→

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىinto a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed
2. 2
   ترشيحThe catalyst is filtered
3. 3
   أخرىseparated
4. 4
   استخلاصether is extracted
5. 5
   غسيلAfter the ether layer is washed with water and with saturated salt water
6. 6
   أخرىdried
7. 7
   أخرىthe ether is evaporated

الإجراء التجريبي

Pour 1.88 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine, 0.4 g of 10% palladium-carbon, 0.55 g of magnesium oxide, 60 ml of ethanol, and 45 ml of water, into a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed. The catalyst is filtered and separated, then ether is extracted. After the ether layer is washed with water and with saturated salt water, and dried, the ether is evaporated. The resultant impure product is repeatedly refined, and 0.9 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine is obtained.

المصدر