تفاعل #45429

معادلة التفاعل

solution

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

→

desired product

المردود 89.0%

4-amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

المردود 89.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered through diatomaceous earth (Celite®)
2. 2
   غسيلThe pad was washed with THF and dichloromethane
3. 3
   تركيزthe combined filtrates were concentrated

الإجراء التجريبي

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

المصدر