تفاعل #45416

معادلة التفاعل

3-bromo-4-chlorothieno[3,2-c]pyridine

NH4OH

→

desired product

المردود 94.0%

3-bromothieno[3,2-c]pyridin-4-amine

المردود 94.0%

المذيبات

p-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىprepared
2. 2
   تركيزThe mixture was concentrated to half its original volume
3. 3
   workup.ADDITIONdiluted with water
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   غسيلThe combined organic extracts were washed with brine
6. 6
   تجفيفdried (MgSO4)
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated

الإجراء التجريبي

A mixture of 3-bromo-4-chlorothieno[3,2-c]pyridine (prepared according to the procedure described in Bull. Soc. Chim. Belges 1970, 79, 407-414, 3 g, 12 mmol), concentrated aqueous NH4OH (100 mL), and p-dioxane (100 mL) was sealed in a stainless steel, high-pressure reactor and stirred for 18 hours at 150° C. The mixture was concentrated to half its original volume, diluted with water, and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4), filtered, and concentrated to provide 2.6 g (94%) of the desired product. 1H NMR (DMSO-d6, 400MHz) δ 7.83 (d, 1H), 7.77 (s, 1H), 7.26 (d, 1H), 6.48 (br s, 2H); MS m/e 229 (M+H)+.

المصدر