تفاعل #45374

معادلة التفاعل

2,4,6-Trichloropyridine

Methylamine

→

2,6-Dichloro-4-methylamino-pyridine

المذيبات

ethanol

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   ترشيحThe product was filtered
3. 3
   غسيلwashed with methyl t-butyl ether (1,500 ml)
4. 4
   أخرىdried
5. 5
   أخرىto yield A1.6 (1200 g, 68%)

الإجراء التجريبي

2,4,6-Trichloropyridine (1800 g, 9.89 mol) was dissolved in ethanol (1800 mL). Methylamine 40% solution in ethanol (6.3 L) was added over 1 h and 40 min maintaining the reaction temperature between 20-25° C. The reaction was stirred for 14 hours at room temperature and concentrated. The product was filtered, washed with methyl t-butyl ether (1,500 ml) and dried to yield A1.6 (1200 g, 68%)

المصدر