تفاعل #45288

معادلة التفاعل

8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

HCl

→

1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter refluxing for 12 h
2. 2
   أخرىthe solvent was removed

الإجراء التجريبي

8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (3.7 g, 16 mmol) was added to a solution of 5% HCl (45 mL) and acetone (8 mL). After refluxing for 12 h, the solvent was removed to give crude 1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride which was used in the next reaction.

المصدر