تفاعل #452426

معادلة التفاعل

2-iodopropane

2-(4-pyrazolyl)-1-ethanol

sodium carbonate

→

title compound

المردود 26.0%

2-(1-isopropyl-1H-pyrazol-4-yl)-1-ethanol

المردود 26.0%

المذيبات

dimethylformamide

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was then cooled to ambient and
2. 2
   تركيزthen concentrated under reduced pressure
3. 3
   أخرىThe residue was partitioned between water and dichloromethane
4. 4
   غسيلThe organic phase was then washed with water
5. 5
   تجفيفwas then dried over sodium sulfate
6. 6
   تركيزThe remaining organics were concentrated under reduced pressure

الإجراء التجريبي

To a solution of 1.0 gm (9.0 mMol) 2-(4-pyrazolyl)-1-ethanol in 36 mL dimethylformamide were added 2.38 gm (22.5 mMol) sodium carbonate followed by the dropwise addition of a solution of 0.89 mL (9.0 mMol) 2-iodopropane in 8 mL dimethylformamide. The reaction mixture was heated to 100° C. for 18 hours. The reaction mixture was then cooled to ambient and then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. The organic phase was then washed with water followed by saturated aqueous sodium chloride and was then dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 0.36 gm (26.0%) of the title compound as a brown oil.

المصدر