تفاعل #45232

معادلة التفاعل

SnCl2.2H2O

3-(3-amino-phenyl)-propionic acid ethyl ester

NaNO2

→

3-(3-hydrazino-phenyl)-propionic acid ethyl ester

المذيبات

HCl

HCl

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction solution was stirred for an additional 2 h at RT
2. 2
   ترشيحThe precipitate was filtered
3. 3
   غسيلwashed with ethanol and ether

الإجراء التجريبي

To a solution of 3-(3-amino-phenyl)-propionic acid ethyl ester (14 g, 72.5 mmol) in concentrated HCl (200 mL) was added an aqueous solution (10 mL) of NaNO2 (5 g, 72.5 mmol) at 0° C. and the resulting mixture was stirred for 1 h. A solution of SnCl2.2H2O (33 g, 145 mmol) in concentrated HCl (150 mL) was then added at 0° C. The reaction solution was stirred for an additional 2 h at RT. The precipitate was filtered and washed with ethanol and ether to give 3-(3-hydrazino-phenyl)-propionic acid ethyl ester as a white solid, which was used without further purification.

المصدر