تفاعل #45231

معادلة التفاعل

3-(3-nitro-phenyl)-acrylic acid ethyl ester

→

3-(3-amino-phenyl)-propionic acid ethyl ester

المردود 97.1%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthen filtered over celite
2. 2
   أخرىAfter removal the solvent

الإجراء التجريبي

A mixture of 3-(3-nitro-phenyl)-acrylic acid ethyl ester (16.5 g, 74.6 mmol) and Pd/C (1.65 g) in methanol (200 mL) was stirred under 40 psi of H2 at RT for 2 h then filtered over celite. After removal the solvent, 14 g of 3-(3-amino-phenyl)-propionic acid ethyl ester was obtained and used directly without further purification. 1H-NMR (400 MHz, CDCl3): 7.11 (t, J=5.6 Hz, 1H), 6.67 (d, J=7.2 Hz, 1H), 6.63-6.61 (m, 2H), 4.13 (q, J=7.2 Hz, 2H), 2.87 (t, J=8.0 Hz, 2H), 2.59 (t, J=7.6 Hz, 2H), 1.34 (t, J=6.8 Hz, 3H).

المصدر