تفاعل #4519

معادلة التفاعل

palmitoyl-L-Ala-D-Glu(OH)OBzl

N-hydroxysuccinimide

dicyclohexylcarbodiimide

→

palmitoyl-L-Ala-D-Glu(OSu)OBzl

المذيبات

tetrahydrofuran

chloroform

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitate was filtered off
2. 2
   غسيلwashed with chloroform
3. 3
   تركيزThe filtrate was concentrated in vacuo
4. 4
   workup.ADDITIONthe diisopropylether was added to the residue
5. 5
   أخرىThe product was collected
6. 6
   أخرىdried

الإجراء التجريبي

To a solution of palmitoyl-L-Ala-D-Glu(OH)OBzl (1)(1.84 g) in a mixture of tetrahydrofuran (20 ml) and chloroform (30 ml) were added N-hydroxysuccinimide (425 mg) and dicyclohexylcarbodiimide (728 mg). The reaction mixture was kept for 18 hours at room temperature and the precipitate was filtered off and washed with chloroform. The filtrate was concentrated in vacuo and the diisopropylether was added to the residue. The product was collected and dried to afford palmitoyl-L-Ala-D-Glu(OSu)OBzl (2)(170 g).

المصدر