تفاعل #451803

معادلة التفاعل

1-(2-pyrimidinyl)piperazine

bromine

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product

المردود 62.0%

5-Bromo-2-(1-piperazinyl)pyrimidine

المردود 62.0%

المذيبات

HCl

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated to 100° until dissipation of the red color
2. 2
   ترشيحThe mixture is filtered
3. 3
   درجة الحرارةcooled
4. 4
   استخلاصextracted with ether
5. 5
   استخلاصThe dried extract (MgSO4)
6. 6
   تركيزwas concentrated in vacuo

الإجراء التجريبي

This example serves to illustrate procedure B of Scheme 2. To an ice-cooled solution of 1-(2-pyrimidinyl)piperazine (16.4 g, 0.1 mole) in 1N HCl (100 mL) was added dropwise bromine (15.98 g, 0.1 mole). After stirring at 0° for 0.5 hr, the mixture was heated to 100° until dissipation of the red color had occurred. The mixture is filtered, cooled, made alkaline with 50% NaOH and extracted with ether. The dried extract (MgSO4) was concentrated in vacuo to provide 14.5 g (62%) of product, m.p. 73°-75°.

المصدر